What is SanRx?

Following 30 years of research, SanRx was founded in 2004 by an experienced scientific and business team, including strong scientific and business advisors and internationally renowned scientific collaborators. Their contributions are published in key scientific publications.

Timeline of Discovery »

What are Calcium Pterins?

Calcium Pterins are a proprietary family of novel, non-toxic, oral immunomodulators. They are covered by global patents (filed 1995-2012).

Pterins (from the Greek pteron = wing) are naturally-occurring heterocyclic compounds responsible for the vibrant color of butterfly wings. SanRx products are made from synthetic versions.

Calcium Pterins are non toxic as they are comprised of calcium and pterin, both of which are part of human chemistry.

How were they discovered?

In the 1970's while at UCLA, a research team joined by Dr. Moheno had consistently observed a fluorescent blue spot in the chromatograms of urine from cancer patients. The blue spot was determined to be pterin-6-aldehyde. Several pterins were subsequently shown by high pressure liquid chromatography (HPLC) to have altered concentrations in the urine of cancer patients.

Search of scientific literature revealed some pterins possess anti-tumor and immuno-modulatory properties. Study of the chemistry of "active" pterins led to successful testing of calcium pterin for antitumor activity. Further refinement of the calcium pterin structure led to the synthesis DCP, a second active pterin, by Dr. Wolfgang Pfleiderer, and to the in vivo testing and patenting of DCP by SanRx.

What does Calcium Pterin do?

Normally, the immune system recognizes immune imbalanced cells, which can escape the immune system by activating the Indoleamine 2,3-Dioxygenase (IDO) pathway, and which is a feedback inhibitor of Th1 Inflammatory Immune Response. Calcium Pterins have been shown to inhibit IDO, Inhibiting IDO means that the immune imbalanced cells cannot escape the immune system in this way.

What conditions have been researched with Calcium Pterins?

Successful published animal model testing has been carried out against:

  • Breast Cancer

  • Infectious diseases (Hepatitis B; tuberculosis [BCG])

  • Diabetes

  • See Publications »

These other IDO disorders are potentially target indications:

  • Neurodegenerative disorders (e.g., major depression, Alzheimer's)

  • Arthritis

Calcium folate (ImmunoPterin), being chemically similar to calcium pterin, is undergoing testing for activities similar to those found with calcium pterins. FDA has established that folic acid helps with:

  • Weight control

  • Neural tube defects

FDA has established that calcium helps with:

  • Colon/rectal cancer

  • Osteoporosis

  • Hypertension

  • Weight control

Why is SanRx different?

SanRx is different because their immunomodulatory products are orally-administered and without toxic side-effects, like hair loss and nausea. As SanRx continues its research and testing, the potential to address many worldwide diseases has surfaced, making its compounds valuable across a wide market spectrum.

As of 2011, there were no approved products in the IDO Modulators category, making SanRx's compounds potentially the first in this class.

Other oral cancer treatments:

Xeloda is the one of the few oral products used in Breast Cancer, but with only 15-28% effectiveness.

Selective Estrogen Receptor Modulators (SERMs) like Tamoxifen (oral) are only effective in treating estrogen receptor-positive breast cancers and tumors have shown to develop resistance. Tamoxifen also has many troubling side effects.